Luca Degli Esposti

Differential Adherence to Free and Single‑Pill Combination of Rosuvastatin/Ezetimibe: Findings from a Real‑World Analysis in Italy

Abstract Introduction Adherence to cardiovascular drug treatment can significantly benefit from a reduced pill burden, but data on this matter derived from real-life settings are currently scanty. This analysis assessed the possible changes in adherence in patients treated with rosuvastatin and ezetimibe (ROS/EZE) as free multi-pill combination who switched to ROS/EZE as single-pill combination in… Leggi tutto »Differential Adherence to Free and Single‑Pill Combination of Rosuvastatin/Ezetimibe: Findings from a Real‑World Analysis in Italy

Un modello di Activity- Based Costing applicato al processo di gestione dei pazienti con emicrania presso l’IRCCS Fondazione Mondino

An Activity-Based Costing model applied to the management process of patients with migraine at IRCCSMondino FoundationBackground and aim: The ageing of the general population, with the increase in chronic diseases, poses theneed for using technological innovation to face the growing healthcare needs. The present analysis applied theActivity-Based Costing tool in migraine patients followed at the… Leggi tutto »Un modello di Activity- Based Costing applicato al processo di gestione dei pazienti con emicrania presso l’IRCCS Fondazione Mondino

Differenze di genere e ipercolesterolemia: evidenze real-world dallo studio WECARE (Women Effective CArdiovascular Risk Evaluation)

Gender differences and hypercholesterolemia: real-world evidence from the study WECARE (Women EffectiveCArdiovascular Risk Evaluation)Introduction: The therapeutic control of LDL-cholesterol is essential in cardiovascular prevention, as recommendedby the recent guidelines.Objective: To evaluate gender differences in terms of demographic and clinical characteristics, treatment pattern,treatment adherence and healthcare costs in patients on lipid-lowering therapy, stratified by cardiovascular riskin… Leggi tutto »Differenze di genere e ipercolesterolemia: evidenze real-world dallo studio WECARE (Women Effective CArdiovascular Risk Evaluation)

Real world evidence: patients with alopecia areata in Italy

BACKGROUN D: This real-world analysis aimed at characterizing patients hospitalized for alopecia areata (AA ) in Italy, focusing on comorbidities, treatment patterns and the economic burden for disease management.METHODS: Administrative databases of healthcare entities covering 8.9 million residents were retrospectively browsed to include patients of all ages with hospitalization discharge diagnosis for AA from 2010… Leggi tutto »Real world evidence: patients with alopecia areata in Italy

Analisi del percorso terapeutico e del consumo di risorse sanitarie in pazienti diabetici in trattamento insulinico: uno studio di real-world evidence su un campione di ASL della regione Sicilia

Italian reports indicate that more than one-third of patients with type 2 diabetes (T2D) require insulin therapy within 8 years of diagnosis, and commonly basal insulin represents the frontline option. An observational analysis was conducted with the aim of investigating patients treated with basal insulin alone in a sample of Local health Units of Sicily… Leggi tutto »Analisi del percorso terapeutico e del consumo di risorse sanitarie in pazienti diabetici in trattamento insulinico: uno studio di real-world evidence su un campione di ASL della regione Sicilia

Analisi real-world della epidemiologia e della gestione terapeutica dei pazienti affetti da fibrosi polmonare idiopatica in un contesto di pratica clinica italiana

La fibrosi polmonare idiopatica (IPF) è spesso diagnosticata tardivamente, con conseguente ritardo nell’inizio di terapie in grado di rallentare la progressione di malattia e il declino della funzione polmonare. Lo studio, condotto in un setting di reale pratica clinica italiana, ha valutato l’impatto dell’intervallo diagnostico di IPF sul burden clinico ed economico della patologia, focalizzandosi su epidemiologia, pattern terapeutico,… Leggi tutto »Analisi real-world della epidemiologia e della gestione terapeutica dei pazienti affetti da fibrosi polmonare idiopatica in un contesto di pratica clinica italiana

A real-world analysis of outcomes and healthcare costs of patients on perindopril/indapamide/amlodipine single-pill vs. multiple-pill combination in Italy

This analysis compared adherence, cardiovascular (CV) events and all-cause mortality incidence, and healthcare costs among hypertensive patients treated with perindopril (PER)/indapamide (IND)/amlodipine (AML) in single-pill combination (SPC) vs. multiple-pill combination, in a real-world setting in Italy. In this observational retrospective analysis of Italian administrative databases, adult patients treated with PER/IND/AML between 2010 and 2020 were… Leggi tutto »A real-world analysis of outcomes and healthcare costs of patients on perindopril/indapamide/amlodipine single-pill vs. multiple-pill combination in Italy

Profile, Healthcare Resource Consumption and Related Costs in ANCA-Associated Vasculitis Patients: a Real-World Analysis in Italy

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare autoimmune diseases triggeringinflammation of small vessels. This real-world analysis was focused on the most common AAV forms, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), to describe patients’ demographic and clinical characteristics,therapeutic management, disease progression, and the related economic burden. A retrospective analysis was conducted on administrative… Leggi tutto »Profile, Healthcare Resource Consumption and Related Costs in ANCA-Associated Vasculitis Patients: a Real-World Analysis in Italy

Burden of Illness in Follicular Lymphoma with Multiple Lines of Treatment, Italian RWE Analysis

This real-world analysis investigated patients with follicular lymphoma in Italy receivingthree or more treatment lines (3L), focusing on therapeutic pathways with their rebounds onhealthcare resource consumptions and costs. Data were retrieved from administrative databases fromhealthcare entities covering about 13.3 million residents. Adults diagnosed with follicular lymphomawere identified between January 2015 and June 2020, and among… Leggi tutto »Burden of Illness in Follicular Lymphoma with Multiple Lines of Treatment, Italian RWE Analysis

A retrospective analysis of treatment patterns, drug discontinuation and healthcare costs in Crohn’s disease patients treated with biologics

Background/aims: This real-world analysis evaluated the persistence and direct healthcare costs of Crohn’s Disease (CD) patients treated with biologics in Italy. Methods: A retrospective analysis on administrative databases of Italian healthcare entities, covering 10.4 million residents, was performed. Adult CD patients under biologics between 2015 and 2020 were in- cluded and attributed to first/second treatment… Leggi tutto »A retrospective analysis of treatment patterns, drug discontinuation and healthcare costs in Crohn’s disease patients treated with biologics