The Integrated Multidisciplinary Pathway for Large-Scale Management of Dyslipidemia in High-Risk Patients (ENNA) Project: Rationale and Project Design
Atherosclerotic cardiovasculardiseaseisaleadingcauseofmorbidityandmortalityglobally,significantly
influenced bymodifiable riskfactors,particularlyhypercholesterolemia.Despitetheavailabilityofeffective
lipid-reducing drugs,achievingthelow-densitylipoproteincholesterol(LDL-C)targetlevelsremainsasignif-
icant challengeinclinicalpractice,contributingtopersistentlyhighratesofcardiovascularevents.TheintE-
grated multidiscipliNarypathwayforlarge-scalemaNagementofdyslipidemiAinhigh-riskpatients(ENNA)
Project wasdesignedtoaddressthealarmingratesofsuboptimallipidmanagementinpatientsathighand
very-high riskintheprovinceofEnna,Sicily.ThisprogramaimstooptimizeLDL-Ccontrolthroughaninte-
grated caremodelthatfosterscollaborationamongpharmacists,generalpractitioners,andcardiologists,ulti-
mately promotingapatient-centeredapproachtotherapy.Thepatientswhoareeligibleareidentified using
data-driven methodsthroughprescriptionclaims,laboratoryresults,andhospitaldischargedata,facilitated
by localpharmacies.Generalpractitionersplayacrucialroleastheprimarycareprovidersforinitiatingor
optimizing lipid-reducingtherapy,whereascardiologistsareinvolvedinmanagingmorecomplexcases
requiring specializedintervention.TheprimaryobjectiveoftheENNAProjectistoincreasethepercentageof
patients atgreatriskinwhomLDL-Ctargetsareachieved,improvingoveralllipidmanagementandthera-
peutic adherence.